hydrophobic toxin; interferes with cell envelope biosynthesis, causes membrane invaginations together with delocalization of the cell wall synthesis machinery, triggers autolysis, and inhibits protein biosynthesis
locus
new_2273515_2273748
function
stability of prophage SPß
product
hydrophobic class I toxin
Genomic Context
categories
[category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.17|Toxins, antitoxins and immunity against toxins] → [category|SW 4.3.17.1|Type 1 TA systems][SW|Categories] containing this gene/protein
[SW|toxins, antitoxins and immunity against toxins], [SW|SP-beta prophage], [SW|membrane proteins]Gene
Coordinates on the chromosome
2,273,515 -> 2,273,748
Protein
[SW|Localization]
membrane protein (based on the presence of a trans-membrane domain) [Pubmed|22229825]Expression and Regulation
Operon
''[SW|bsrG]'' [Pubmed|22229825]Sigma factor
[SW|SigA] [Pubmed|22229825]Regulation
expression increases at the onset of the stationary phase [Pubmed|22229825]the mRNA is destabilized upon interaction with the antitoxin RNA [protein|search|SR4] [Pubmed|22229825]the mRNA is degraded by [protein|search|Rnc], [protein|search|Rny] and [protein|search|Rnr] [Pubmed|22229825]Regulatory mechanism
the mRNA is degraded by [protein|search|Rnc], [protein|search|Rny] and [protein|search|Rnr], degradation is enhanced at higher temperature [Pubmed|22229825]at elevated temperatures, [SW|Rny] and [SW|RnjA] are responsible for the enhance degradation of the mRNA [Pubmed|26802042]Additional information
half-life of the mRNA: 15 min [Pubmed|22229825]Labs working on this gene/protein
[SW|Sabine Brantl], Jena, GermanyReferences
Original publications
18948176,20525796,23969414,22229825,26234942,26802042 
