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cydD [2019-09-02 13:19:38]
ABC transporter required for expression of cytochrome bd (ATP-binding protein)
function
required for expression of cytochrome bd
product
ABC transporter (ATP-binding protein)
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.1|ABC transporters] → [category|SW 1.2.1.3|Regulatory ABC transporters][category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.2|Respiration] → [category|SW 2.1.2.1|Terminal oxidases][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,973,364 3,975,091
The protein
Protein family
[SW|ABC transporter superfamily] (according to UniProt)[SW|Domains]
has both a membrane-spanning and an ATP-binding domain [Pubmed|10092453]Structure
[PDB|2HYD] (from Staphylococcus aureus, 28% identity) [pubmed|16943773][SW|Localization]
cell membrane [Pubmed|10092453]Expression and Regulation
Operons
genes
[gene|C0459C0D45E31561D281E016D86CD80DCAF13357|cydA]-[gene|E66EAB3C172ED8D1D26C675A7338B8153FB66987|cydB]-[gene|A65576E0261F1950A0DAD72B2432D97AB3EB2AA5|cydC]-[gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]
description
[Pubmed|16207915]
sigma factors
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF]: sigma factor, [PubMed|16497325], in [regulon|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|SigF regulon]regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon][protein|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex]: repression, [Pubmed|15231791], in [regulon|B5EF521437323EF43F08E5EFDB5C798616CA499A|Rex regulon][protein|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD]: activation, [Pubmed|17322317], in [regulon|1E829D639BADDC6BDC9B5FB4C97A632A53FDDB24|ResD regulon]regulation
expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|17322317]view in new tabgenes
[gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]
description
[pubmed|16497325]
regulation
expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|17322317]view in new tabBiological materials
Mutant
MGNA-B748 (cydD::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1747 NBRP B. subtilis, Japan]BKE38730 ([gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE38730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGGCAAAATCCATTCTTCTT, downstream forward: _UP4_TAAAAGACAGCCCTAAAAGGBKK38730 ([gene|244BF9E397FDB0691FFAA8C9D419B0AE417CACE1|cydD]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK38730 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGGCAAAATCCATTCTTCTT, downstream forward: _UP4_TAAAAGACAGCCCTAAAAGGReferences
15231791,16207915,17322317,10092453,16497325,9852001,15231791,17322317,24958725,16943773