rapC [Tue Dec 13 2016 11:16:30 GMT+0100 (CET)]

response regulator aspartate phosphatase, controls ComA activity

locus: BSU03770

pI: 5.00

mw: 45.00 kDa

function: control of ComA activity

product: response regulator aspartate phosphatase

essential: no

synonyms: yclL

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.4|Protein phosphatases]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.2|Response regulator aspartate phosphatase]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]

[SW|Categories] containing this gene/protein

• [SW|genetic competence], [SW|protein modification], [SW|transcription factors and their control], [SW|quorum sensing]

This gene is a member of the following [SW|regulons]

• [SW|CodY regulon], [SW|ComA regulon]

Gene

Coordinates on the chromosome (coding sequence): 428,831 -> 429,979

The protein

Catalyzed reaction/ biological activity

• control of [protein|search|ComA] activity [Pubmed|12950917]

Protein family

• RAP family (according to Swiss-Prot)

Effectors of protein activity

• binding of [protein|search|PhrC] to [protein|search|RapC] prevents it from binding [protein|search|ComA] [Pubmed|12950917]

[SW|Interactions]

• [protein|search|RapC]-[protein|search|PhrC] [Pubmed|12950917], [protein|search|RapC]-[protein|search|ComA] [Pubmed|12950917]

Expression and Regulation

Operon

• ''[protein|search|rapC]-[protein|search|phrC]'' [Pubmed|10464187]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|10464187]

Regulation

• repressed during growth in the presence of branched chain amino acids ([protein|search|CodY]) [Pubmed|10464187]
• expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]

Regulatory mechanism

• [protein|search|ComA]: transcription activation ([protein|search|ComA]) [Pubmed|16091051]
• [protein|search|CodY]: transcription repression [Pubmed|10464187]

References

• 12950917,16091051,10464187,26582911