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metE
Molecular weight
86.64 kDa
Function
biosynthesis of methionine
Product
methionine synthase
Genomic Context
Categories containing this gene/protein
Gene
Coordinates
1,383,320 1,385,608
The protein
Catalyzed reaction/ biological activity
5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine --> L-methionine + tetrahydropteroyltri-L-glutamate (according to UniProt)Protein family
vitamin-B12 independent methionine synthase family (single member, according to UniProt)Modification
phosphorylated on ser/ thr/ tyr PubMed, S-cysteinylation after diamide stress (C719) PubMedCys719 and Cys730 are S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species PubMed PubMedMetE is generally most strongly S-bacillithiolated by NaOCl stress in B. subtilis and other Bacillus species PubMed PubMed Structure
1T7L (from Thermotoga maritima, 44% identity, 61% similarity) PubMed Additional information
Expression and Regulation
Biological materials
Mutant
1A607 ( metE::erm), PubMed, available at BGSCBKE13180 (metE::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTTTCTCCTCCTTTAT, downstream forward: _UP4_TAATTTGAAAAAACCATCTGBKK13180 (metE::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATTGTTTCTCCTCCTTTAT, downstream forward: _UP4_TAATTTGAAAAAACCATCTG References
Reviews
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Original Publications
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