lmrB [Mon Aug 31 2015 13:52:11 GMT+0200 (CEST)]

lincomycin-resistance protein (multidrug resistance pump)

locus: BSU02670

pI: 9.70

mw: 51.00 kDa

function: resistance to lincomycin

product: lincomycin-resistance protein

essential: no

synonyms: yccA

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.12|Other transporters]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.13|Resistance against toxins/ antibiotics]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

syns: yccA

[SW|Categories] containing this gene/protein

• [SW|transporters/ other], [SW|resistance against toxins/ antibiotics], [SW|membrane proteins]

This gene is a member of the following [SW|regulons]

• [SW|LmrA regulon]

The protein

Protein family

• EmrB family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YcnB], [protein|search|YhcA]

[SW|Localization]

• cell membrane (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|lmrA]-[protein|search|lmrB]'' [Pubmed|15317768]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|12499232]

Regulation

• induced by flavonoids such as quercetin ([protein|search|LmrA])[Pubmed|17483215]

Regulatory mechanism

• [protein|search|LmrA]: transcription repression [Pubmed|15317768]

Biological materials

Mutant

• GP1701 (''[protein|search|lmrB]''::''aphA3''), available in [SW|Jörg Stülke]'s lab
• GP1703 (''[protein|search|lmrB]''::''aphA3'' ''[protein|search|ycnB]''::''spc''), available in [SW|Jörg Stülke]'s lab

References

• 15317768,17483215,12499232,21815947