dynA [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

dynamin-like protein, mediates membrane fusion

locus: BSU22030

pI: 5.00

mw: 137.00 kDa

function: fusion of membranes

product: dynamin-like protein

essential: no

synonyms: ypbR

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.2|Cell shape]
• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.7|Membrane dynamics]
• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.8|Cell division] → [category|SW 1.1.8.2|Other genes]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|cell division], [SW|cell shape], [SW|membrane dynamics], [SW|membrane proteins]

Gene

** Coordinates on the chromosome (coding sequence): 2,312,529 -> 2,316,110

Phenotype of a mutant

• sensitive to membrane stress-inducing antibiotics [Pubmed|26530236]

The protein

Catalyzed reaction/ biological activity

• mediates nucleotide independent membrane fusion ''in vitro'' [Pubmed|21205012]

Protein family

• gerABKA family (according to Swiss-Prot)

[SW|Domains]

• two separate dynamin-like subunits and GTPase domains [Pubmed|21205012]

[SW|Cofactors]

• Mg(2 ) [Pubmed|21205012]

[SW|Localization]

• associated to the membrane [Pubmed|21205012]
• membrane, forms foci at the site of septation [Pubmed|23060960]
• colocalizes with [protein|search|FtsZ] [Pubmed|23249255]
• highly dynamic membrane-associated protein; upon membrane damage, DynA localizes into large and static assemblies [Pubmed|26530236]

[SW|Interactions]

• forms oligomers [Pubmed|21205012]
• [protein|search|DynA]-[rny|search|RNase Y] [Pubmed|23060960]
• [protein|search|DynA]-[protein|search|YneK] [Pubmed|23060960]
• [protein|search|DynA]-[protein|search|YwpG] [Pubmed|23060960]

Expression and Regulation

Operon

• ''dynA'' [Pubmed|8396117]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8396117]

Biological materials

Mutant

• BKE22030 ''dynA''::''erm trpC2'' is available from the Bacillus Genetic Stock Center

References

Reviews

• 23109540,20970992,21599493,15040446

Original publications

• 8396117,21205012,20525796,23060960,23249255,26530236