dynA

dynamin-like protein, mediates membrane fusion

Locus: BSU_22030

Isoelectric point: 5.72

Molecular weight: 137.16 kDa

Protein length: 1193 aa

Gene length: 3582 bp

Function: fusion of membranes

Product: dynamin-like protein

Essential: no

Synonyms: ypbR

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell shape
• Cellular processes → Cell envelope and cell division → Membrane dynamics
• Cellular processes → Cell envelope and cell division → Cell division → Other genes
• Groups of genes → Membrane proteins

Gene

Coordinates: 2,312,529 2,316,110

Phenotypes of a mutant

• sensitive to membrane stress-inducing antibiotics PubMed

The protein

Catalyzed reaction/ biological activity

• mediates nucleotide independent membrane fusion in vitro PubMed

Domains

• two separate dynamin-like subunits and GTPase domains PubMed

Cofactors

• Mg(2 ) PubMed

Localization

• associated to the membrane PubMed
• membrane, forms foci at the site of septation PubMed
• colocalizes with FtsZ PubMed
• highly dynamic membrane-associated protein; upon membrane damage, DynA localizes into large and static assemblies PubMed

Expression and Regulation

Operons

• Genes: dynA-ypbS-ypzF
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

Biological materials

Mutant

• MGNA-A877 (ypbR::erm), available at the NBRP B. subtilis, Japan
• BKE22030 (dynA::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAAGTCTGAACCCCTTTG, downstream forward: _UP4_TAAAATTCAGTTGGCTTGTA
• BKK22030 (dynA::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CATAAGTCTGAACCCCTTTG, downstream forward: _UP4_TAAAATTCAGTTGGCTTGTA

References

Reviews

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Original publications

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