SubtiBank SubtiBank
accA
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accA

acetyl-CoA carboxylase (alpha subunit)
Locus
BSU_29200
Isoelectric point
6.09
Molecular weight
36.18 kDa
Protein length
325 aa Sequence Blast
Gene length
978 bp Sequence Blast
Function
production of malonyl-CoA, the substrate for fatty acid biosynthesis
Product
acetyl-CoA carboxylase (alpha subunit))
Essential
yes
E.C.
6.4.1.2
Synonyms

Genomic Context

      
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Categories containing this gene/protein

Gene

Coordinates
2,987,731 2,988,708

Phenotypes of a mutant

  • essential PubMed
  • The protein

    Catalyzed reaction/ biological activity

  • acetyl-CoA + N6-carboxybiotinyl-L-lysyl-[protein] --> malonyl-CoA + N6-biotinyl-L-lysyl-[protein] (according to UniProt)
  • Protein family

  • accA family (single member, according to UniProt)
  • Domains

  • CoA carboxyltransferase C-terminal domain (aa 38-292) (according to UniProt)
  • Structure

  • 2F9I (from Staphylococcus aureus; equivalent to AccD-AccA, 64% identity) PubMed
  • Localization

  • cytoplasm (according to Swiss-Prot), Membrane-proximal (Spotty) PubMed
  • Expression and Regulation

    Operons

    Genes
    Description

    Regulatory mechanism

  • Spo0A: activation, PubMed, in Spo0A regulon
  • Regulation

  • expressed under conditions that trigger sporulation (Spo0A) PubMed
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    Biological materials

    Expression vectors

  • pGP1021: purification from E. coli with an N-terminal His-tag, with TEV cleavage site, (in pETM-11), available in Jörg Stülke's lab
  • pGP1024: purification from E. coli with an N-terminal Strep-tag, with TEV cleavage site, (in pGP172), available in Jörg Stülke's lab
  • pGP1723: purification from B. subtilis with an C-terminal Strep-tag, for SPINE, (in pGP382), available in Jörg Stülke's lab
  • GFP fusion

  • GP1490 (spc, based on pBP43), available in Jörg Stülke's lab
  • Two-hybrid system

  • B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Jörg Stülke's lab
  • FLAG-tag construct

  • GP1487 (spc, based on pGP1331), available in Jörg Stülke's lab
  • References

    Reviews

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    Original Publications

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