degradative acetoacetyl-CoA thiolase
function
mother cell metabolism, leucine utilization
product
degradative acetoacetyl-CoA thiolase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.2|Utilization of amino acids] → [category|SW 2.3.2.9|Utilization of branched-chain amino acids][category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.4|Sporulation proteins/ other][SW|Categories] containing this gene/protein
[SW|sporulation proteins], [SW|utilization of amino acids]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon], [SW|SigE regulon]The protein
Catalyzed reaction/ biological activity
2 acetyl-CoA = CoA + acetoacetyl-CoA [Pubmed|19935659]Protein family
thiolase family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|FadA], [protein|search|YhfS]Structure
[PDB|3SS6] (the protein of ''B. anthracis'', 44% identity, 73% similarity)Expression and Regulation
Operon
''[protein|search|mmgA]-[protein|search|mmgB]-[protein|search|mmgC]-[protein|search|mmgD]-[protein|search|mmgE]-[protein|search|yqiQ]'' [Pubmed|8759838][SW|Sigma factor]
[protein|search|SigE] [Pubmed|15699190,8759838]Regulation
expressed early during sporulation in the mother cell ([protein|search|SigE]) [Pubmed|15699190,8759838]repressed by glucose ([protein|search|CcpA]) [Pubmed|8759838]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|8759838]References
18246303,8759838,15699190,19935659,23840410 
