S protein of biotin ECF transporter
function
uptake of biotin
product
S protein of biotin ECF transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.3|ECF transporter][category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.3|ECF transporter] → [category|SW 1.2.3.2|The substrate-specific S components of the ECF transporters][category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.1|Biosynthesis/ acquisition of biotin][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|ECF transporter], [SW|biosynthesis of cofactors], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|BirA regulon]Gene
Coordinates on the chromosome (coding sequence)
1,111,925 -> 1,112,485
The protein
Catalyzed reaction/ biological activity
uptake of biotin [Pubmed|17301237]Protein family
bioY family (according to Swiss-Prot)Structure
[PDB|4DVE] (BioY from ''Lactococcus lactis'', 35% identity, 71% similarity) [Pubmed|22891302][SW|Localization]
membrane associated [Pubmed|18763711][SW|Interactions]
[protein|search|YbaF]-[protein|search|YhfU] [Pubmed|20497229]Expression and Regulation
Operon
''[SW|yhfU]-[SW|yhfT]-[SW|yhfS]-[SW|yhfR]'' [Pubmed|22383849]Regulation
repressed in the presence of biotin ([protein|search|BirA]) [Pubmed|11717296]Regulatory mechanism
[protein|search|BirA]: transcription repression [Pubmed|11717296]References
21437340,20497229,22574898,24362466,17301237,22891302,18763711,22383849,11717296,12368242 
