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spoIIGA [Mon Aug 31 2015 13:54:11 GMT+0200 (CEST)]
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spoIIGA [Mon Aug 31 2015 13:54:11 GMT+0200 (CEST)]

Pro-SigE protease
locus
BSU15310
pI
8.55
mw
34.00 kDa
function
maturation of SigE
product
Pro-SigE protease
essential
no
synonyms

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.3|Proteolysis during sporulation/ germination]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors]
  • [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.3|Sporulation/ other]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]
  • [SW|Categories] containing this gene/protein

  • [SW|proteolysis], [SW|sigma factors and their control], [SW|sporulation/ other], [SW|membrane proteins]
  • This gene is a member of the following [SW|regulons]

  • [SW|SinR regulon], [SW|Spo0A regulon]
  • The protein

    Protein family

  • peptidase U4 family (according to Swiss-Prot)
  • Effectors of protein activity

  • [SW|SpoIIGA] protease activity is stimulated by the interaction with [SW|SpoIIR] in the intermembrane space between the forespore and the mother cell [Pubmed|22111992]
  • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • [SW|Interactions]

  • [SW|SpoIIGA]-[protein|search|SigE] (Processing) [Pubmed|21362630]
  • [SW|SpoIIR]-[SW|SpoIIGA] [Pubmed|22111992]
  • Expression and Regulation

    Operon

  • ''[SW|spoIIGA]-[protein|search|sigE]-[protein|search|sigG]'' [Pubmed|1902213]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|2512576]
  • Regulation

  • expressed under conditions that trigger sporulation ([SW|Spo0A]) [http://www.ncbi.nlm.nih.gov/sites/entrez/8288522,15687200 PubMed]
  • Regulatory mechanism

  • repression by [protein|search|SinR]
  • [SW|Spo0A]: transcription activation [http://www.ncbi.nlm.nih.gov/sites/entrez/8288522,15687200 PubMed]
  • References

  • 19581368,1537790,2448286,8288522,8231806,8002606,8730857,1744037,9287022,7585939,18296515,8288522,15687200