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bacC [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]
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bacC [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

bacilysin biosynthesis oxidoreductase
locus
BSU37720
pI
4.96
mw
27.00 kDa
function
biosynthesis of the antibiotic bacilysin
product
bacilysin biosynthesis oxidoreductase
essential
no
synonyms
ywfD, ipa-82d

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.6|Miscellaneous metabolic pathways] → [category|SW 2.6.6.1|Biosynthesis of antibacterial compounds]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.15|Biosynthesis of antibacterial compounds]
  • [SW|Categories] containing this gene/protein

  • [SW|miscellaneous metabolic pathways], [SW|biosynthesis of antibacterial compounds]
  • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|CodY regulon], [SW|ScoC regulon]
  • Gene

    Coordinates on the chromosome (coding sequence)
    3,872,105 -> 3,872,872

    The protein

    Catalyzed reaction/ biological activity

  • oxidation of the C(7)-hydroxyl, penultimate step in bacilysin biosynthesis [Pubmed|23317005]
  • Protein family

  • short-chain dehydrogenases/reductases (SDR) family (according to Swiss-Prot)
  • Expression and Regulation

    Operon

  • ''[protein|search|bacA]-[protein|search|bacB]-[protein|search|bacC]-[protein|search|bacD]-[protein|search|bacE]-[protein|search|bacF]'' [Pubmed|12372825]
  • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|19801406]
  • Regulatory mechanism

  • [protein|search|CodY]: transcription repression [Pubmed|12372825,21709425]
  • [protein|search|AbrB]: transcription repression [Pubmed|12697329,21709425]
  • [protein|search|ScoC]: transcription repression [Pubmed|19801406]
  • References

  • 15609023,12372825,21948839,19801406