clsA [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

cardiolipin synthase, major enzyme

locus: BSU36590

pI: 9.00

mw: 55.00 kDa

function: biosynthesis of phospholipids

product: cardiolipin synthase, major enzyme

essential: no

synonyms: ywnE

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of lipids], [SW|membrane proteins]

Gene

Coordinates on the chromosome (coding sequence): 3,762,664 -> 3,764,112

The protein

Catalyzed reaction/ biological activity

• 2 Phosphatidylglycerol = diphosphatidylglycerol glycerol (according to Swiss-Prot)

Protein family

• Cardiolipin synthase subfamily (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|YwiE], [protein|search|YwjE]

[SW|Localization]

• cell membrane at the septum, this localization depends on two C-terminal helices [Pubmed|26708983,15743965]

Biological materials

Mutant

• MGNA-A198 (ywnE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/198 NBRP B. subtilis, Japan]

References

• 18820022,14973018,16514141,15743965,26708983