lpdV [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

2-oxoisovalerate dehydrogenase (E3 subunit, dihydrolipoamide dehydrogenase)

Locus: BSU24060

Isoelectric point: 4.89

Molecular weight: 48.00 kDa

Function: utilization of branched-chain keto acids

Product: 2-oxoisovalerate dehydrogenase
(E3 subunit, dihydrolipoamide dehydrogenase)

Essential: no

E.C.: 1.8.1.4

Synonyms: yqiV, bkd

Genomic Context

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Categories containing this gene/protein

• Metabolism → Amino acid/ nitrogen metabolism → Utilization of amino acids → Utilization of branched-chain amino acids

Categories containing this gene/protein

• utilization of amino acids

This gene is a member of the following regulons

• BkdR regulon, CodY regulon, SigL regulon

Gene

Coordinates on the chromosome (coding sequence): 2,500,104 -> 2,501,528

The protein

Catalyzed reaction/ biological activity

• Protein N(6)-(dihydrolipoyl)lysine + NAD⁺ = protein N(6)-(lipoyl)lysine + NADH (according to Swiss-Prot)

Protein family

• class-I pyridine nucleotide-disulfide oxidoreductase family (according to Swiss-Prot)

Paralogous protein(s)

• AcoL, PdhD

Structure

• 2YQU (from Thermus thermophilus (hb8 mutant), 42% identity, 55% similarity)

Expression and Regulation

Operon

• ptb-bcd-buk-lpdV-bkdAA-bkdAB-bkdB PubMed

Sigma factor

• SigL PubMed

Regulation

• induced in the presence of isoleucine or valine (BkdR) PubMed

Regulatory mechanism

• CodY: transcription repression PubMed
• BkdR: transcription activation PubMed

References

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