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ganR [2019-02-04 18:26:35]
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ganR [2019-02-04 18:26:35]

transcriptional repressor of the galactan utilization operon
locus
BSU34170
pI
5.40
mw
37.31 kDa
protein length
330 aa Sequence Blast
gene length
993 bp Sequence Blast
function
regulation of galactan utilization
product
transcriptional repressor ([SW|LacI family])
essential
no
synonyms
yvfJ,ganR
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.24|Utilization of galactan]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

    • Gene

    Coordinates
    3,508,659 3,509,651

    The protein

    Protein family

  • [SW|LacI family]

    • Effectors of protein activity

  • released from DNA upon binding of galactobiose [pubmed|22383849,27501980]

    • Structure

  • [PDB|2HSG] (B. megaterium [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA], 25% identity)

    • Expression and Regulation

    Operons

    genes
    [gene|1F787F70C87DEB221709579122D63C2322A84E56|ganR]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [protein|1F787F70C87DEB221709579122D63C2322A84E56|GanR]: repression, [pubmed|22383849], in [regulon|1F787F70C87DEB221709579122D63C2322A84E56|GanR regulon]

    • regulation

  • induced by galactan (binding of galactobiose to [protein|1F787F70C87DEB221709579122D63C2322A84E56|GanR]) [Pubmed|28617843]
    • view in new tab

    Biological materials

    Mutant

  • GP815 ([gene|1F787F70C87DEB221709579122D63C2322A84E56|ganR]::spc) available in the [SW|Jrg Stlke]'s lab
  • BKE34170 ([gene|1F787F70C87DEB221709579122D63C2322A84E56|ganR]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE34170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTATCTGCCTCCATTA, downstream forward: _UP4_TAAGGATGACTTAGGACACT
  • BKK34170 ([gene|1F787F70C87DEB221709579122D63C2322A84E56|ganR]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK34170 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTGTATCTGCCTCCATTA, downstream forward: _UP4_TAAGGATGACTTAGGACACT

    • References

  • 2104611,9287030,27501980,22383849