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iolJ [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]
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iolJ [Tue Dec 13 2016 11:16:37 GMT+0100 (CET)]

2-deoxy-5-keto-gluconic acid-6-phosphate aldolase, formation of dihydroxyacetone phosphate and malonic semialdehyde (6th reaction)
locus
BSU39670
pI
4.85
mw
31.00 kDa
function
myo-inositol catabolism
product
2-deoxy-5-keto-gluconic acid-6-phosphate aldolase,
formation of dihydroxyacetone phosphate and
malonic semialdehyde (6th reaction)
essential
no
ec
4.1.2.29
synonyms
fbaB, yxdI
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.16|Utilization of inositol]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources]

    • This gene is a member of the following [SW|regulons]

  • [SW|CcpA regulon], [SW|IolR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    4,073,081 -> 4,073,953

    The protein

    Catalyzed reaction/ biological activity

  • 5-dehydro-2-deoxy-D-gluconate 6-phosphate = glycerone phosphate + malonate semialdehyde (according to Swiss-Prot)

    • Protein family

  • IolJ subfamily (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|FbaA]

    • Effectors of protein activity

  • inhibited by alpha-keto acids [Pubmed|24624]

    • Expression and Regulation

    Operon

  • ''[protein|search|iolA]-[protein|search|iolB]-[protein|search|iolC]-[protein|search|iolD]-[protein|search|iolE]-[protein|search|iolF]-[protein|search|iolG]-[protein|search|iolH]-[protein|search|iolI]-[protein|search|iolJ]'' [Pubmed|9226270]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|9226270]

    • Regulation

  • repressed by glucose ([protein|search|CcpA]) [Pubmed|10666464]
  • induced by inositol ([protein|search|IolR]) [Pubmed|9887260,9226270]

    • Regulatory mechanism

  • [protein|search|IolR]: transcription repression [Pubmed|9887260,9226270]
  • [protein|search|CcpA]: transcription repression [Pubmed|10666464]

    • Labs working on this gene/protein

  • [SW|Yasutaro Fujita], University of Fukuyama, Japan
  • [[Ken-ichi Yoshida]], Kobe University, Japan

    • References

  • 9226270,18310071,9887260,18310071