flavodoxin, ribonucleoside-diphosphate reductase
function
synthesis of deoxyribonucleoside triphosphates
product
ribonucleoside-diphosphate reductase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.5|Biosynthesis/ acquisition of nucleotides/ other][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|essential genes]This gene is a member of the following [SW|regulons]
[SW|NrdR regulon], [SW|ResD regulon]Gene
Coordinates on the chromosome (coding sequence)
1,868,617 -> 1,869,009
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
Provides oxidant (O2•-) for assembly of dimanganic-tyrosyl radical (MnIII2-Y•) cofactor in [protein|search|NrdF]. [Pubmed|23402532]Protein family
nrdI family (according to Swiss-Prot)Paralogous protein(s)
[protein|search|YosM][SW|Cofactors]
FMN [Pubmed|21561096]Structure
[PDB|1RLJ][SW|Interactions]
[protein|search|NrdI]-[protein|search|NrdF] [Pubmed|23402532][protein|search|NrdI]-[protein|search|YumC] [Pubmed|27559930]Expression and Regulation
Operon
''[protein|search|nrdI]-[protein|search|nrdE]-[protein|search|nrdF]-[protein|search|ymaB]'' [Pubmed|16885274][SW|Sigma factor]
[protein|search|SigA] [Pubmed|16885274]Regulation
expressed under anaerobic conditions ([protein|search|ResD]) [Pubmed|16885274]Regulatory mechanism
[protein|search|ResD]: transcription activation [Pubmed|16885274][SW|NrdR]: transcription repression (predicted) [Pubmed|15949864]Additional information
A [protein|search|ncRNA] is predicted between '[protein|search|ymzA]' and '[protein|search|nrdI]' [PubMed|20525796]References
Reviews
Original Publications
27559930,26507228,8969495,21561096,23402532,16885274,12682299,20525796,15949864 
