nrdI

flavodoxin, ribonucleoside-diphosphate reductase

Locus: BSU_17370

Isoelectric point: 8.58

Molecular weight: 14.46 kDa

Protein length: 130 aa

Gene length: 393 bp

Function: synthesis of deoxyribonucleoside triphosphates

Product: ribonucleoside-diphosphate reductase

Essential: yes

Synonyms: ymaA

Genomic Context

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Categories containing this gene/protein

• Metabolism → Nucleotide metabolism → Biosynthesis/ acquisition of nucleotides → Biosynthesis/ acquisition of nucleotides/ other
• Groups of genes → Essential genes

Gene

Coordinates: 1,868,617 1,869,009

Phenotypes of a mutant

• essential PubMed

The protein

Catalyzed reaction/ biological activity

• Provides oxidant (O₂^-) for assembly of dimanganic-tyrosyl radical (Mn^III₂-Y) cofactor in NrdF. PubMed

Protein family

• nrdI family (with YosM, according to UniProt)

Paralogous protein(s)

• YosM

Cofactors

• FMN PubMed

Structure

• 1RLJ

Expression and Regulation

Operons

• Genes: nrdI-nrdE-nrdF-ymaB
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • ResD: activation, PubMed, in ResD regulon
  • NrdR: repression, (predicted) PubMed, in NrdR regulon
  • PerR: transcription repression, PubMed, in PerR regulon

  Regulation

  • expressed under anaerobic conditions (ResD) PubMed

  Additional information

  • A ncRNA is predicted between 'ymzA' and 'nrdI' PubMed

• Genes: ymzA-nrdI-nrdE-nrdF-ymaB
  Description: PubMed

References

Reviews

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Original Publications

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