resD [Sun Nov 27 2016 18:16:17 GMT+0100 (CET)]

two-component response regulator (OmpR family), regulation of aerobic and anaerobic respiration, activates expression of target genes in response to oxygen limitation

Locus: BSU23120

Isoelectric point: 5.00

Molecular weight: 27.00 kDa

Function: regulation of aerobic and anaerobic respiration
respiration

Product: two-component response regulator (OmpR family)

Essential: no

Synonyms: ypxD

Genomic Context

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Categories containing this gene/protein

• Metabolism → Electron transport and ATP synthesis → Regulators of electron transport
• Information processing → Regulation of gene expression → Transcription factors and their control → Two-component system response regulators
• Groups of genes → Phosphoproteins → Phosphorylation on an Asp residue

Categories containing this gene/protein

• regulators of electron transport, transcription factors and their control, membrane proteins, phosphoproteins

This gene is a member of the following regulons

• CcpA regulon, PhoP regulon, ResD regulon

Gene

Coordinates on the chromosome (coding sequence): 2,417,181 -> 2,417,903

The protein

Protein family

• OmpR family of two-component response regulators

Modification

• phosphorylated by ResE on an Asp residue

Effectors of protein activity

• phosphorylation likely affects DNA-binding activity

Localization

• cell membrane (according to Swiss-Prot)

Interactions

• ResD interacts with the RNA polymerase PubMed
• ResE-ResD

Expression and Regulation

Sigma factor

• resA: SigA PubMed
• resD: SigA PubMed

Regulation

• expressed under anaerobic conditions (ResD) PubMed
• expressed under conditions of phosphate limitation (PhoP) PubMed
• repressed by glucose (CcpA) PubMed
• induced by daptomycin PubMed

Regulatory mechanism

• ResD: transcription activation PubMed
• PhoP: transcription activation PubMed
• CcpA: transcription repression PubMed

Labs working on this gene/protein

• Marion Hulett, University of Illinois at Chicago, USA Homepage

References

Reviews

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Original publications

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