SubtiBank SubtiBank
gntR [Mon Nov 14 2016 13:02:41 GMT+0100 (CET)]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

gntR [Mon Nov 14 2016 13:02:41 GMT+0100 (CET)]

transcriptional repressor (GntR family) of the gntR-gntK-gntP-gntZ operon
locus
BSU40050
pI
5.00
mw
28.00 kDa
function
regulation of gluconate utilization
product
transcriptional repressor of the gluconate operon
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.13|Utilization of gluconate]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other]

    • [SW|Categories] containing this gene/protein

  • [SW|utilization of specific carbon sources], [SW|transcription factors and their control]

    • This gene is a member of the following [SW|regulons]

  • [SW|AbrB regulon], [SW|CcpA regulon], [SW|GntR regulon]

    • Gene

    Coordinates on the chromosome (coding sequence)
    4,113,417 -> 4,114,148

    The protein

    Protein family

  • [SW|GntR family] of transcription factors

    • Effectors of protein activity

  • gluconate acts as molecular inducer

    • Expression and Regulation

    Operon

  • ''[protein|search|gntR]-[protein|search|gntK]-[protein|search|gntP]-[protein|search|gntZ]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/10746760 PubMed1][http://www.ncbi.nlm.nih.gov/sites/entrez/3020045 PubMed2]

    • [SW|Sigma factor]

  • [protein|search|SigA] [Pubmed|3020045]

    • Regulation

  • induced by gluconate ([protein|search|GntR]) [Pubmed|3020045]
  • repressed by glucose ([protein|search|CcpA]) [Pubmed|8370661]

    • Regulatory mechanism

  • [protein|search|GntR]: transcription repression [Pubmed|3020045]
  • [protein|search|CcpA]: transcription repression [Pubmed|10666464]
  • [protein|search|AbrB]: transcription activation [Pubmed|20817675]

    • References

  • 8370661,8808939,8288545,7642511,7476858,8596444,3011959,2163901,3037520,2492998,9106211,2419835,2124676,3020045,10746760,8510140,2843515,7476858,3020045,1659648,21106498,22900538,220817675