function
biosynthesis of methionine
product
cystathionine beta-lyase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|S-box]Gene
Coordinates on the chromosome (coding sequence)
1,259,606 -> 1,260,778
The protein
Catalyzed reaction/ biological activity
L-cystathionine + H2O = L-homocysteine + NH3 + pyruvate (according to Swiss-Prot)Protein family
trans-sulfuration enzymes family (according to Swiss-Prot)[SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|metI]-[protein|search|metC]'' [Pubmed|11832514][SW|Sigma factor]
[protein|search|SigA] [Pubmed|11832514]Regulation
repressed by casamino acids [Pubmed|12107147]induced by methionine starvation ([protein|search|S-box]) [Pubmed|10094622]Regulatory mechanism
[protein|search|S-box]: transcription termination/ antitermination, the [protein|search|S-box] [SW|riboswitch] binds S-adenosylmethionine resulting in termination [Pubmed|10094622]Biological materials
Mutant
1A944 ( ''metC''::''kan''), [Pubmed|11832514], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A944&Search=1A944 BGSC]1A940 ( ''metC''::''spec''), [Pubmed|11832514], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A940&Search=1A940 BGSC]References
19258532,11832514,18039762,12107147 
