guanylate kinase (GMP:dATP, dGMP:ATP)
function
GTP biosynthesis
product
guanylate kinase (GMP:dATP, dGMP:ATP)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.5|Nucleotide metabolism] → [category|SW 2.5.2|Biosynthesis/ acquisition of nucleotides] → [category|SW 2.5.2.1|Biosynthesis/ acquisition of purine nucleotides][category|SW 3|Information processing] → [category|SW 3.5|Targets of second messengers] → [category|SW 3.5.3|Targets of (p)ppGpp][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.1|Phosphorylation on an Arg residue][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of nucleotides], [SW|essential genes], [SW|phosphoproteins]Gene
Coordinates on the chromosome (coding sequence)
1,641,949 -> 1,642,563
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP GMP = ADP GDP (according to Swiss-Prot) Protein family
guanylate kinase-like domain (according to Swiss-Prot)Modification
phosphorylated on Arg-134 and/or Arg-149[Pubmed|22517742]Effectors of protein activity
inhibition of enzymatic activity by (p)ppGpp during the ´stringent response´[Pubmed|22981860]Structure
[PDB|1S4Q] (from ''Mycobacterium tuberculosis h37rv'', 39% identity, 60% similarity)[http://pdb.org/pdb/search/structidSearch.do?structureId=4QRH 4QRH] (from ''Staphylococcus aureus'', complex with pppGpp) [Pubmed|25661490][SW|Localization]
cytoplasm (according to Swiss-Prot)References
Reviews
Original publications
22517742,22981860,24722991,24682323,25661490,11078735 
