dltB [Wed Feb 24 2016 15:14:33 GMT+0100 (CET)]

D-alanine transfer from Dcp to undecaprenol-phosphate, alanylation of teichoic acid provides some resistance against positively charged antimicrobial peptides

Locus: BSU38510

Isoelectric point: 9.00

Molecular weight: 46.00 kDa

Function: biosynthesis of teichoic acid

Product: D-alanine transfer from Dcp to undecaprenol-phosphate

Essential: no

Synonyms: ipa-4r

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall synthesis → Biosynthesis of teichoic acid
• Cellular processes → Transporters → Transporters/ other → Other transporters
• Metabolism → Additional metabolic pathways → Biosynthesis of cell wall components → Biosynthesis of teichoic acid
• Lifestyles → Coping with stress → Cell envelope stress proteins (controlled by SigM, V, W, X, Y)
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• cell wall synthesis, transporters/ other, biosynthesis of cell wall components, cell envelope stress proteins (controlled by SigM, V, W, X, Y), membrane proteins

This gene is a member of the following regulons

• SigD regulon, SigM regulon, SigX regulon, Spo0A regulon, stringent response, YvrHb regulon

Gene

Coordinates on the chromosome (coding sequence): 3,953,783 -> 3,954,970

Phenotypes of a mutant

• more sensitive to nisin PubMed

The protein

Protein family

• membrane-bound acyltransferase family (according to Swiss-Prot)

Localization

• membrane associated PubMed

Expression and Regulation

Operon

• dltA-dltB-dltC-dltD-dltE PubMed

Sigma factor

• SigD PubMed, SigM PubMed, SigX PubMed

Regulation

• RelA dependent downregulation (Class I) during stringent response PubMed
• repressed under conditions that trigger sporulation (Spo0A) PubMed
• expression is reduced in a SigV mutant PubMed

Regulatory mechanism

• activated by YvrHb PubMed
• Spo0A: transcription repression PubMed

References

Reviews

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Original publications

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