DNA uptake, major component of the pseudopilus
function
genetic competence
product
major pseudopilin
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|ComK regulon]Gene
Coordinates on the chromosome (coding sequence)
2,557,673 -> 2,557,969
Phenotypes of a mutant
knockout has complete loss of transformation competence [Pubmed|1968455]The protein
Protein family
comGC family (according to Swiss-Prot)[SW|Localization]
cell surface [Pubmed|9723928]localizes to the cell membrane and the cytoplasm [Pubmed|21278288]localizes to one single cell pole in the majority of the cells [Pubmed|21278288][SW|Interactions]
[SW|ComGB]-[SW|ComGC] [Pubmed|15083159][protein|search|ComC]-[SW|ComGC] [Pubmed|9723928]forms large complexes (the [SW|pseudopilus]) [Pubmed|21278288]Expression and Regulation
Operon
''[SW|comGA]-[SW|comGB]-[SW|comGC]-[SW|comGD]-[SW|comGE]-[SW|comGF]-[SW|comGG]-[protein|search|spoIIIL]'' [Pubmed|2507524][SW|Sigma factor]
[protein|search|SigA] [Pubmed|2507524]Regulation
repressed by casamino acids [Pubmed|12107147]Regulatory mechanism
[protein|search|ComK]: transcription activation [Pubmed|8196543]References
Reviews
Original publications
11744713,11814663,9422590,16751195,9723928,1968455,7783624,21278288,12107147,2507524,8196543 
