lipM [Tue Dec 13 2016 11:16:34 GMT+0100 (CET)]

octanoyltransferase

locus: BSU24530

pI: 5.00

mw: 32.00 kDa

function: biosynthesis of lipoic acid

product: octanoyltransferase

essential: no

ec: 2.3.1.181

synonyms: yqhM

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.7|Biosynthesis and scavenging of lipoic acid]

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

Gene

Coordinates on the chromosome (coding sequence): 2,543,968 -> 2,544,804

The protein

Catalyzed reaction/ biological activity

• transfers the octanoyl moiety from octanoyl-acyl carrier protein to the lipoyl domains of the 2-oxoacid dehydrogenases via a thioester-linked octanoyl-LipM intermediate [Pubmed|20882995]

Structure

• [PDB|3A7A] (from ''E. coli'', 25% identity) [Pubmed|20089862]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Regulation

• induced by valine [Pubmed|21338421]

References

Reviews

• 27074917

Original publications

• 20882995,20089862