parE [Tue Sep 06 2016 17:15:10 GMT+0200 (CEST)]

subunit of DNA topoisomerase IV

locus: BSU18090

pI: 6.00

mw: 72.00 kDa

function: chromosome segregation and compaction

product: subunit of DNA topoisomerase IV

essential: yes

ec: 5.99.1.-

synonyms: grlB

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.3|DNA condensation/ segregation]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|DNA condensation/ segregation], [SW|essential genes]

This gene is a member of the following [SW|regulons]

• [SW|LexA regulon]

Gene

Coordinates on the chromosome (coding sequence): 1,933,477 -> 1,935,444

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Protein family

• type II topoisomerase family (according to Swiss-Prot)

Paralogous protein(s)

• [protein|search|GyrB]

Structure

• [PDB|4I3H] (from ''Streptococcus pneumoniae'', 70% identity) [Pubmed|23965305]

[SW|Localization]

• Nucleoid (Homogeneous) [Pubmed|16479537]
• uniformly distributed throughout the cell [Pubmed|9539793]

[SW|Interactions]

• [protein|search|ParC]-[protein|search|ParE] [Pubmed|9539793]

Expression and Regulation

Operon

• ''[protein|search|parE]-[protein|search|parC]'' [Pubmed|16267290]

Regulation

• induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]

Regulatory mechanism

• [protein|search|LexA]: transcription repression [Pubmed|16267290]

Additional information

• term-seq has identified a potential novel regulatory RNA element including an intrinsic transcription terminator upstream of ''parE'' [Pubmed|27120414]

References

• 16272394,9539793,16267290,16479537,23965305,27120414