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fra [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]
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fra [Tue Dec 13 2016 11:16:31 GMT+0100 (CET)]

frataxin-like protein, required for the biosynthesis of iron-sulfur clusters, intracellular carrier to provide iron for the ferrochelatase HemH
locus
BSU05750
pI
5.00
mw
14.00 kDa
function
intracellular iron channeling, biosynthesis of iron-sulfur clusters
product
frataxin-like protein
essential
no
synonyms
ydhG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.3|Biosynthesis of iron-sulfur clusters]

    • [SW|Categories] containing this gene/protein

  • [SW|iron metabolism]

    • Gene

    Coordinates on the chromosome (coding sequence)
    621,847 -> 622,218

    Phenotypes of a mutant

  • severe growth phenotype associated with a broadly disturbed iron homeostasis [Pubmed|21744456]

    • The protein

    Catalyzed reaction/ biological activity

  • transfers iron onto the B. subtilis SUF system ([protein|search|SufU]-[protein|search|SufS]) for iron-sulfur cluster biosynthesis [Pubmed|21744456]

    • [SW|Cofactors]

  • Fe(2) is bound with high affinity [Pubmed|20087498]

    • Structure

  • [PDB|2OC6]

    • [SW|Interactions]

  • the protein is active as a dimer [Pubmed|20087498]
  • ([protein|search|Fra])2-[protein|search|SufU], requires iron [Pubmed|20087498]
  • ([protein|search|Fra])-[protein|search|HemH], requires iron, Kd of 1.63 ± 0.02 μM [Pubmed|25826316]
  • [SW|Fra]-[SW|SufS] [Pubmed|27382962]

    • Biological materials

    Mutant

  • available in [SW|Mohamed Marahiel]'s lab

    • References

  • 20087498,21744456,25826316,27382962