SubtiBank SubtiBank
fra [2017-8-11 16:0:3]
You are currently viewing an outdated version of SubtiWiki. Please use the newest version!

fra [2017-8-11 16:0:3]

frataxin-like protein, required for the biosynthesis of iron-sulfur clusters, intracellular carrier to provide iron for the ferrochelatase HemH
locus
BSU05750
pI
5.38
mw
14.28 kDa
protein length
123 aa Sequence Blast
gene length
369 bp Sequence Blast
function
intracellular iron channeling, biosynthesis of iron-sulfur clusters
product
frataxin-like protein
essential
no
synonyms
ydhG
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.5|Iron metabolism] → [category|SW 2.6.5.3|Biosynthesis of iron-sulfur clusters]

    • Gene

    Coordinates
    621,847 → 622,218

    Phenotypes of a mutant

  • severe growth phenotype associated with a broadly disturbed iron homeostasis [Pubmed|21744456]

    • The protein

    Catalyzed reaction/ biological activity

  • transfers iron onto the B. subtilis SUF system ([protein|C0C30D2A6D3DF7A66063010044D370BD36D27DBF|SufU]-[protein|88ACE6B79534338F7C72F107B35A0B2384007088|SufS]) for iron-sulfur cluster biosynthesis [Pubmed|21744456]

    • [SW|Cofactors]

  • Fe(2+) is bound with high affinity [Pubmed|20087498]

    • Structure

  • [PDB|2OC6]

    • Expression and Regulation

    Operons

    genes
    [gene|188833286AD73DF7730954D47BD676D8137679E9|fra]
    description
    [Pubmed|22383849]
    view in new tab

    Biological materials

    Mutant

  • MGNA-C182 (ydhG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2180 NBRP B. subtilis, Japan]
  • available in [SW|Mohamed Marahiel]'s lab

    • References

  • 20087498,21744456,25826316,27382962