dapF [Tue Dec 13 2016 11:16:36 GMT+0100 (CET)]

diaminopimelate epimerase

locus: BSU32170

pI: 4.51

mw: 30.00 kDa

function: biosynthesis of lysine and peptidoglycan

product: diaminopimelate epimerase

essential: yes

ec: 5.1.1.7

synonyms: yutL

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.1|Cell wall synthesis] → [category|SW 1.1.1.1|Biosynthesis of peptidoglycan]
• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.6|Biosynthesis/ acquisition of lysine/ threonine]
• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.1|Biosynthesis of cell wall components] → [category|SW 2.6.1.1|Biosynthesis of peptidoglycan]
• [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

[SW|Categories] containing this gene/protein

• [SW|cell wall synthesis], [SW|biosynthesis/ acquisition of amino acids], [SW|Biosynthesis of cell wall components], [SW|essential genes]

Gene

Coordinates on the chromosome (coding sequence): 3,306,040 -> 3,306,894

Phenotypes of a mutant

• essential [Pubmed|12682299]

The protein

Catalyzed reaction/ biological activity

• LL-diaminopimelate --> meso-diaminopimelate

Protein family

• diaminopimelate epimerase family (according to Swiss-Prot)

Structure

• [PDB|2OTN] (from ''Bacillus anthracis str. ames'', 62% identity, 75% similarity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)