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hisG [2019-08-09 13:45:17]
ATP phosphoribosyltransferase
function
biosynthesis of histidine
product
ATP phosphoribosyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine]Gene
Coordinates
3,587,551 3,588,192
The protein
Catalyzed reaction/ biological activity
1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)Protein family
ATP phosphoribosyltransferase family (single member, according to UniProt)Structure
[PDB|2VD2][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]-[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]-[gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]-[gene|88ED20DFEBD5D7B985F99D4494142FBA699A1E91|hisB]-[gene|DEB3122A3EA36545759FAA6F86F71F971CA5F011|hisH]-[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]-[gene|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF]-[gene|5C84CA2A9E22173E144F519389F545F107A267D9|hisI]
description
[Pubmed|12107147]
regulatory mechanism
[protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]regulation
expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]expression depends on functional [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]view in new tabBiological materials
Mutant
BKE34920 ([gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE34920 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTTGGCATCGCCATTGTGA, downstream forward: _UP4_GTTGTGGAAGGAGAGACGGCBKK34920 ([gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK34920 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CTTTGGCATCGCCATTGTGA, downstream forward: _UP4_GTTGTGGAAGGAGAGACGGCReferences