SubtiBank SubtiBank
hisG
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hisG

ATP phosphoribosyltransferase
Locus
BSU_34920
Isoelectric point
4.53
Molecular weight
23.47 kDa
Protein length
213 aa Sequence Blast
Gene length
642 bp Sequence Blast
Function
biosynthesis of histidine
Product
ATP phosphoribosyltransferase
Essential
no
E.C.
2.4.2.17
Synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      
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Categories containing this gene/protein

  • Metabolism → Amino acid/ nitrogen metabolism → Biosynthesis/ acquisition of amino acids → Biosynthesis/ acquisition of histidine

    • Gene

    Coordinates
    3,587,551 3,588,192

    The protein

    Catalyzed reaction/ biological activity

  • 1-(5-phospho-β-D-ribosyl)-ATP + diphosphate --> 5-phospho-α-D-ribose 1-diphosphate + ATP (according to UniProt)

    • Protein family

  • ATP phosphoribosyltransferase family (single member, according to UniProt)

    • Structure

  • 2VD2

    • Localization

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operons

    Genes
    hisZ-hisG-hisD-hisB-hisH-hisA-hisF-hisI
    Description
    PubMed

    Regulatory mechanism

  • YlxR: regulation, PubMed, in YlxR regulon

    • Regulation

  • expression during spore germination is strongly reduced under conditions of osmotic stress PubMed
  • expression depends on functional YlxR PubMed
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    Biological materials

    Mutant

  • BKE34920 (hisG::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CTTTGGCATCGCCATTGTGA, downstream forward: _UP4_GTTGTGGAAGGAGAGACGGC
  • BKK34920 (hisG::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_CTTTGGCATCGCCATTGTGA, downstream forward: _UP4_GTTGTGGAAGGAGAGACGGC

    • References

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