protein acetylase for the control of AcsA activity
function
control of AcsA activity
product
Gcn5-related N-acetyltransferase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.5|Protein acetylases/ deacetylases][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|utilization of lipids], [SW|protein modification]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon]Gene
Coordinates on the chromosome (coding sequence)
3,040,092 -> 3,040,724
The protein
Catalyzed reaction/ biological activity
acetylates (and thereby inactivates) [protein|search|AcsA] on Lys-549 [Pubmed|18487328] [Pubmed|19136592]Protein family
acetyltransferase family (according to Swiss-Prot) Gcn5-relatedN-acetyltransferase [Pubmed|18487328]Expression and Regulation
Operon
''[protein|search|acuA]-[protein|search|acuB]-[protein|search|acuC]'' [Pubmed|7934817][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7913927]Regulation
repressed by glucose (3.4-fold) ([protein|search|CcpA]) [Pubmed|7913927,12850135]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|7913927]Biological materials
Mutant
GP1211 (''acuA''::''kan''), available in [SW|Jörg Stülke]'s labGP1255 (''[protein|search|acuA]''::''kan'' ''[protein|search|yjcK]''::''cat'' ''[protein|search|ynaD]''::''spec'' ''[protein|search|yoaA]''::''tet''), available in [SW|Jörg Stülke]'s labReferences
7913927,22900538,16855235,7934817,19136592,18487328,12850135 
