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murP [2018-07-26 14:01:39]
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murP [2018-07-26 14:01:39]

N-acetyl muramic acid-specific phosphotransferase system, EIIBC component of the PTS
locus
BSU01680
pI
8.50
mw
47.44 kDa
protein length
455 aa Sequence Blast
gene length
1365 bp Sequence Blast
function
N-acetyl muramic acid uptake and phosphorylation
product
N-acetyl muramic acid-specific phosphotransferase system, EIIBC component
essential
no
ec
2.7.1.69
synonyms
ybbF
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components]
  • [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.2|Phosphotransferase system] → [category|SW 1.2.2.2|Sugar specific PTS proteins]
  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.17|Utilization of amino sugars]
  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.3|Utilization of nitrogen sources other than amino acids] → [category|SW 2.3.3.3|Utilization of amino sugars]
  • [category|SW 6|Groups of genes] → [category|SW 6.4|Phosphoproteins] → [category|SW 6.4.3|Phosphorylation on a Cys residue]

    • Gene

    Coordinates
    189,790 → 191,157

    The protein

    Catalyzed reaction/ biological activity

  • transport and concomitant phosphorylation of N-acetyl muramic acid

    • Protein family

  • [protein|14ED1AF5038F43F3B151FCBABE6CFC5A2DA3AA6E|PtsI] permease, sucrose permease (Scr) family [Pubmed|10627040]

    • Expression and Regulation

    Operons

    genes
    [gene|0B1F43F43A4DC1574A153DBFBAA5D0A1855F9B61|murQ]-[gene|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]-[gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]-[gene|DEACFD435DB01C4B3ADEF397BEE08E2E7C7FCC36|amiE]-[gene|A5D4BF262BD365DCEBA9358C8DB295E605DE4D84|nagZ]-[gene|005D37F34CA3D6891F7D8FF7A2AFA1CBCB556FFE|ybbC]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [protein|125872506C400CB6B3DAEA8B5130B064DFBA4494|MurR]: repression, [pubmed|30038046], in [regulon|125872506C400CB6B3DAEA8B5130B064DFBA4494|MurR regulon]

    • regulation

  • expressed in late exponential and early stationary phase [Pubmed|20400549]
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    Biological materials

    Mutant

  • MGNA-B950 (ybbF::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1949 NBRP B. subtilis, Japan]
  • BKE01680 (Δ[gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE01680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTAAAACCCCTCCCCTTC, downstream forward: _UP4_TAAATTGTTTCTGTTTTAGG
  • BKK01680 (Δ[gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK01680 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATTAAAACCCCTCCCCTTC, downstream forward: _UP4_TAAATTGTTTCTGTTTTAGG

    • References

  • 10627040,15060041,22383849