ydgH

similar to drug exporter

locus: BSU_05650

pI: 5.14

mw: 95.29 kDa

protein length: 885 aa

gene length: 2658 bp

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.12|Other transporters]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 609,388 612,045

The protein

Protein family

• resistance-nodulation-cell division (RND) (TC 2.A.6) family (with [protein|1B61298ECA583D2112AA56A88358E8A9A55D2C9D|YdfJ] and [protein|AAC32230E3E585932A876737131C3E2C15168B2A|SwrC], according to UniProt)

Structure

• [PDB|6AJF] (from Mycobacterium smegmatis, corresponds to aa 2 ... 370 and 686 ... 885, 24% identity) [pubmed|30682372]

[SW|Localization]

• cell membrane (according to UniProt)

Expression and Regulation

Operons

• genes: [gene|833F4B9ECB609D5EBAD0CAA55E1F601A5C1C3787|ydgG]-[gene|1632474628BEA113F297897D152276A1AB73BAE8|ydgH]
  description: [Pubmed|16267290]

  regulatory mechanism

  • [protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|16267290], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]

  regulation

  • induced by DNA damage ([protein|search|LexA]) [Pubmed|16267290]

Biological materials

Mutant

• MGNA-C161 (ydgH::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2159 NBRP B. subtilis, Japan]
• BKE05650 ([gene|1632474628BEA113F297897D152276A1AB73BAE8|ydgH]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE05650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCACTTGAATTTGATGATTG, downstream forward: _UP4_TAATCGAGAGAAGAGTGATG
• BKK05650 ([gene|1632474628BEA113F297897D152276A1AB73BAE8|ydgH]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK05650 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CCACTTGAATTTGATGATTG, downstream forward: _UP4_TAATCGAGAGAAGAGTGATG

References

• 16267290,21630458,30682372