glutamate-5-semialdehyde dehydrogenase, required for normal and osmoadaptive proline biosynthesis
function
biosynthesis of proline
product
glutamate-5-semialdehyde dehydrogenase
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.2|Biosynthesis/ acquisition of proline][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.6|Coping with hyper-osmotic stress][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids], [SW|coping with hyper-osmotic stress]This gene is a member of the following [SW|regulons]
[SW|T-box]Gene
Phenotypes of a mutant
auxotrophic for proline [Pubmed|21784929]The protein
Catalyzed reaction/ biological activity
L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH (according to Swiss-Prot)Protein family
gamma-glutamyl phosphate reductase family (according to Swiss-Prot)Structure
[PDB|1O20] (from ''Thermotoga maritima'', 46% identity, 67% similarity) [Pubmed|14705032][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operon
''[protein|search|proB]-[protein|search|proA]'' [Pubmed|21233158][SW|Sigma factor]
[protein|search|SigA] [Pubmed|21233158]Regulation
induced by proline limitation ([protein|search|T-box]) [Pubmed|21233158]Regulatory mechanism
[protein|search|T-box]: [SW|RNA switch], transcriptional antitermination [Pubmed|21233158]References
Reviews
Original publications
19258532,21233158,22540663,21784929,17562291,23869754,25344233 
