ktrC [Thu Oct 01 2015 13:51:44 GMT+0200 (CEST)]

low affinity potassium transporter KtrC-KtrD, peripheric membrane component

Locus: BSU14510

Isoelectric point: 5.00

Molecular weight: 24.00 kDa

Function: potassium uptake

Product: low affinity potassium transporter KtrC-KtrD,
peripheric membrane component (proton symport)

Essential: no

Synonyms: ylxV, yzaC, ykqB

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Transporters → Transporters/ other → Metal ion transporter
• Cellular processes → Homeostasis → Metal ion homeostasis (K, Na, Ca, Mg) → Potassium uptake/ export
• Information processing → Targets of second messengers → Targets of c-di-AMP
• Lifestyles → Coping with stress → Coping with hyper-osmotic stress
• Groups of genes → Membrane proteins

Categories containing this gene/protein

• transporters/ other, metal ion homeostasis (K, Na, Ca, Mg), coping with hyper-osmotic stress, membrane proteins

Gene

Coordinates on the chromosome (coding sequence): 1,520,531 -> 1,521,196

The protein

Paralogous protein(s)

• KtrA

Domains

• contains a RCK_N domain at the N-terminus (according to [http://www.uniprot.org/uniprot/?query=domain:RCK N-terminal domain* UniProt])
• contains a c-di-AMP-binding RCK_C domain at the C-terminus (according to [http://www.uniprot.org/uniprot/?query=domain:RCK C-terminal domain* UniProt]) PubMed

Effectors of protein activity

• the protein binds c-di-AMP PubMed

Structure

• 4J7C (the KtrA-KtrB complex, 56% identity) PubMed
• 4XTT (the S. aureus KtrA RCK_C domain in complex with c-di-AMP, 57% identity) PubMed

Localization

• peripheral membrane protein PubMed

Interactions

• KtrC-KtrD PubMed

Expression and Regulation

Operon

• ktrC PubMed

Regulation

• constitutively expressed PubMed

Biological materials

Mutant

• GHB6 (ktrC::spec), PubMed (available in Erhard Bremer's and Jörg Stülke's) labs, available at BGSC as 1A955
• GP2079 (ktrC::tet), available in Jörg Stülke's lab
• GP2083 (D(ktrA-ktrB)::aphA3 DktrC::tet), available in Jörg Stülke's lab

Expression vector

• pGP2907 (N-terminal His-tag, purification from E. coli, in pWH844), available in Jörg Stülke's lab

Labs working on this gene/protein

• Erhard Bremer, University of Marburg, Germany homepage

References

Reviews

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Original publications

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