tryptophan synthase (alpha subunit)
function
biosynthesis of tryptophan
product
tryptophan synthase (alpha subunit)
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.13|Biosynthesis/ acquisition of aromatic amino acids][SW|Categories] containing this gene/protein
[SW|biosynthesis/ acquisition of amino acids]This gene is a member of the following [SW|regulons]
[SW|TRAP regulon]Gene
Coordinates on the chromosome (coding sequence)
2,371,508 -> 2,372,311
The protein
Catalyzed reaction/ biological activity
L-serine 1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan glyceraldehyde 3-phosphate H2O (according to Swiss-Prot)Protein family
UPF0403 family (according to Swiss-Prot)Structure
[PDB|1WQ5] (from ''Escherichia coli'', 35% identity, 53% similarity) [Pubmed|15667212][SW|Interactions]
[protein|search|TrpA]-[protein|search|TrpB]Expression and Regulation
Operon
''[protein|search|aroF]-[protein|search|aroB]-[protein|search|aroH]-[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' (according to [http://dbtbs.hgc.jp/COG/prom/trpEDCFBA-hisC-tyrA-aroE.html DBTBS])''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' [Pubmed|21815947]''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]'' [Pubmed|21815947][SW|Sigma factor]
''[protein|search|trpE]'': [protein|search|SigA] [Pubmed|6436812]Regulation
not expressed if tryptophan is available ([MtrB|search| TRAP]) [Pubmed|1551827]Regulatory mechanism
[MtrB|search| TRAP]: binding to the mRNA in the presence of tryptophan, this results in transcription termination [Pubmed|8419914]Additional information
the mRNA of the ''[protein|search|trpE]-[protein|search|trpD]-[protein|search|trpC]-[protein|search|trpF]-[protein|search|trpB]-[protein|search|trpA]-[protein|search|hisC]-[protein|search|tyrA]-[protein|search|aroE]'' operon strongly accumulates upon depletion of [rny|search|RNase Y] [Pubmed|21815947]the mRNA is substantially stabilized upon depletion of [Rny|search|RNase Y] [PubMed|21815947]References
Reviews
18486479,11893063,11163353,7900177,19387555,12859215 Original publications
14976255,3924737,6436812,2422155,8419914,1551827,21815947 
