repressor of comK, nucleoid associated protein that serves to help repress expression of A T-rich genes, many of which appear to have been acquired by horizontal gene transfer
function
regulation of genetic competence
product
transcriptional repressor
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.5|Transcription factors/ other][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][SW|Categories] containing this gene/protein
[SW|genetic competence], [SW|transcription factors and their control]This gene is a member of the following [SW|regulons]
[SW|AbrB regulon], [SW|Rok regulon], [SW|SinR regulon], [SW|Spo0A regulon]Gene
Coordinates on the chromosome (coding sequence)
1,493,787 -> 1,494,362
Phenotypes of a mutant
higher excision rate of the conjugative transposon ICEBs1 [Pubmed|21085634]The protein
Catalyzed reaction/ biological activity
binds to extended regions of the ''B. subtilis'' genome that are characterized by a high AT content and are known or believed to have been acquired by horizontal gene transfer [Pubmed|21085634] Effectors of protein activity
activity is modulated by interaction with [SW|DnaA] [Pubmed|27902860][SW|Interactions]
[SW|DnaA]-[SW|Rok], to modulate [SW|Rok] activity [Pubmed|27902860]Expression and Regulation
Operon
''rok'' [Pubmed|12354229]Regulation
repressed under conditions that trigger sporulation ([SW|Spo0A]) [Pubmed|14651647]repressed by [protein|search|SinR] [Pubmed|11849533]repressed by [protein|search|Rok] [Pubmed|11849533]repressed during logrithmic growth ([protein|search|AbrB]) [Pubmed|11849533]Regulatory mechanism
[SW|Spo0A]: transcription repression [Pubmed|14651647][protein|search|SinR]: transcription repression [Pubmed|11849533][protein|search|Rok]: transcription repression [Pubmed|11849533][protein|search|AbrB]: transcription repression [Pubmed|11849533]References
Reviews
Original publications
21085634,12354229,14651647,11849533,21097620,15743949,27375604,27902860 
