phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF
function
biosynthesis of histidine
product
phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine]Gene
Coordinates
3,584,317 → 3,585,054
The protein
Catalyzed reaction/ biological activity
1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide (according to Swiss-Prot)Protein family
hisA/hisF family (according to Swiss-Prot)Paralogous protein(s)
[protein|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|HisF]Structure
[PDB|2VEP] (from ''Streptomyces coelicolor'', 41% identity, 58% similarity) [Pubmed|17967415][SW|Localization]
cytoplasm (according to Swiss-Prot)Expression and Regulation
Operons
genes
[gene|E8FD92F48BE16F87D7481262F4E49003A78DE78F|hisZ]-[gene|183C8B4F28E601D670B3D997D333AF2B5C4A4759|hisG]-[gene|03274B80B2DFE0A2939981B0E0CB8C34A9B0B102|hisD]-[gene|88ED20DFEBD5D7B985F99D4494142FBA699A1E91|hisB]-[gene|DEB3122A3EA36545759FAA6F86F71F971CA5F011|hisH]-[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]-[gene|C22C15754859B2510E52622E6A5DFAF97A7AD4E5|hisF]-[gene|5C84CA2A9E22173E144F519389F545F107A267D9|hisI]
description
[Pubmed|12107147]
regulatory mechanism
[protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR]: regulation, [pubmed|30355672], in [regulon|F4097349A563503468A2A14F062AEAC532C7917A|YlxR regulon]regulation
expression during spore [SW|germination] is strongly reduced under conditions of osmotic stress [Pubmed|27766092]expression depends on functional [protein|F4097349A563503468A2A14F062AEAC532C7917A|YlxR] [pubmed|30355672]view in new tabBiological materials
Mutant
1A626 ( ''hisA''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A626&Search=1A626 BGSC]BKE34880 (Δ[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE34880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCCGGATATAATGTAAAAG, downstream forward: _UP4_GCGCTTGAAAGGGTGAAGCGBKK34880 (Δ[gene|148F0C7983250F50676D234DB713E532AA55DDBF|hisA]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK34880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TGCCGGATATAATGTAAAAG, downstream forward: _UP4_GCGCTTGAAAGGGTGAAGCGReferences