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hisA [Mon Aug 31 2015 13:56:59 GMT+0200 (CEST)]
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hisA [Mon Aug 31 2015 13:56:59 GMT+0200 (CEST)]

phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, homologue to HisF
locus
BSU34880
pI
4.84
mw
26.00 kDa
function
biosynthesis of histidine
product
phosphoribosylformimino-5-aminoimidazole
carboxamide ribotide isomerase, homologue to HisF
essential
no
ec
5.3.1.16
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.14|Biosynthesis/ acquisition of histidine]

    • [SW|Categories] containing this gene/protein

  • [SW|biosynthesis/ acquisition of amino acids]

    • The protein

    Catalyzed reaction/ biological activity

  • 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxyribulos-1-ylamino)methylideneamino)-1-(5-phosphoribosyl)imidazole-4-carboxamide (according to Swiss-Prot)

    • Protein family

  • hisA/hisF family (according to Swiss-Prot)

    • Paralogous protein(s)

  • [protein|search|HisF]

    • Structure

  • [PDB|2VEP] (from ''Streptomyces coelicolor'', 41% identity, 58% similarity) [Pubmed|17967415]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Expression and Regulation

    Operon

  • ''[protein|search|hisZ]-[protein|search|hisG]-[protein|search|hisD]-[protein|search|hisB]-[protein|search|hisH]-[protein|search|hisA]-[protein|search|hisF]-[protein|search|hisI]'' [Pubmed|12107147]

    • Regulation

  • repressed by casamino acids [Pubmed|12107147]

    • Biological materials

    Mutant

  • 1A626 ( ''hisA''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A626&Search=1A626 BGSC]

    • References

  • 12107147