recX [2017-8-11 16:0:3]

recombination protein, modulates the SOS response and facilitates RecA-mediated recombinational repair and genetic recombination

locus: BSU08520

pI: 6.29

mw: 30.86 kDa

protein length: 264 aa

gene length: 792 bp

function: DNA repair/ recombination

product: recombination protein

essential: no

synonyms: yfhG

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.5|DNA repair/ recombination] → [category|SW 3.1.5.6|Other proteins]

Gene

Coordinates: 925,633 → 926,427

Phenotypes of a mutant

• reduced natural tranformation with plasmid or chromosomal DNA [Pubmed|23284295]
• drastically reduced survival of mature dormant spores after exposure to ultrahigh vacuum desiccation and ionizing radiation that induce single strand (ss) DNA nicks and double-strand breaks (DSBs) [Pubmed|24285298]

The protein

Catalyzed reaction/ biological activity

• modulates the "length or packing" of a [protein|A44D4677FB70BE8F554BF1001A500F817C7DA95F|RecA] filament, thereby [protein|144E7D10740C5F146403612B8A0C88E02FB9C572|RecX] facilitates the initiation of recombination and increases recombination across species [Pubmed|23284295]

Protein family

• recX family (according to Swiss-Prot)

[SW|Localization]

• forms foci on the nucleoid upon DNA damage [Pubmed|23284295]
• forms foci at the cells poles and/ or the nucleoid upon induction of genetic competence [Pubmed|23284295]

Expression and Regulation

Operons

• genes: [gene|144E7D10740C5F146403612B8A0C88E02FB9C572|recX]-[gene|CEB1A0835C26E14E04BA99F933787C4550A96388|yfhH]
  description: [Pubmed|22383849]

Biological materials

Mutant

• MGNA-C361 (yfhG::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2359 NBRP B. subtilis, Japan]

References

• 23284295,22383849,24285298,24285298