nadC [2017-8-11 16:0:3]

nicotinate-nucleotide diphosphorylase (carboxylating)

locus: BSU27860

pI: 5.18

mw: 31.24 kDa

protein length: 289 aa

gene length: 867 bp

function: NAD biosynthesis

product: nicotinate-nucleotide diphosphorylase (carboxylating)

essential: no

ec: 2.4.2.19

synonyms: yrxB

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]

Gene

Coordinates: 2,847,048 → 2,847,917

The protein

Catalyzed reaction/ biological activity

• Nicotinate D-ribonucleotide + diphosphate + CO₂ = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

Protein family

• nadC/modD family (according to Swiss-Prot)

Structure

• [PDB|1X1O] (from Thermus thermophilus, 45% identity)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|D30D059185DFB828AB0FD07D600DBC3FD0973198|nadB]-[gene|1368734DCC28C618AA173B865784BDDAEA912623|nadC]-[gene|F92F17578F06EF2292D0923662933463D7C86498|nadA]
  description: [Pubmed|8444804]

  sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8444804], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

  regulatory mechanism

  • [protein|510DE075EA964D22C42DEB171509F6CDA600A402|NadR]: repression, [Pubmed|16199587], in [regulon|510DE075EA964D22C42DEB171509F6CDA600A402|NadR regulon]

  regulation

  • repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|16199587]

  additional information

  • An [ncRNA|search|antisense RNA] is predicted for '[protein|search|nadB]' [PubMed|20525796]

References

• 8444804,16199587