nadC [Mon Aug 31 2015 13:56:02 GMT+0200 (CEST)]

nicotinate-nucleotide diphosphorylase (carboxylating)

locus: BSU27860

pI: 5.18

mw: 31.00 kDa

function: NAD biosynthesis

product: nicotinate-nucleotide diphosphorylase (carboxylating)

essential: no

ec: 2.4.2.19

synonyms: yrxB

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.6|Additional metabolic pathways] → [category|SW 2.6.2|Biosynthesis of cofactors] → [category|SW 2.6.2.11|Biosynthesis of NAD(P)]

syns: yrxB

[SW|Categories] containing this gene/protein

• [SW|biosynthesis of cofactors]

This gene is a member of the following [SW|regulons]

• [SW|NadR regulon]

The protein

Catalyzed reaction/ biological activity

• Nicotinate D-ribonucleotide + diphosphate + CO₂ = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate (according to Swiss-Prot)

Protein family

• nadC/modD family (according to Swiss-Prot)

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operon

• ''[protein|search|nadB]-[protein|search|nadC]-[protein|search|nadA]'' [Pubmed|8444804]

[SW|Sigma factor]

• [protein|search|SigA] [Pubmed|8444804]

Regulation

• repressed in the presence of nicotinic acid ([protein|search|NadR]) [Pubmed|16199587]

Regulatory mechanism

• [protein|search|NadR]: transcription repression [Pubmed|16199587]

References

• 8444804,16199587