dhbB [Sat May 21 2016 12:50:52 GMT+0200 (CEST)]

isochorismatase

Locus: BSU31970

Isoelectric point: 4.00

Molecular weight: 34.00 kDa

Function: biosynthesis of the siderophore bacillibactin

Product: isochorismatase

Essential: no

E.C.: 3.3.2.1

Synonyms

Genomic Context

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Categories containing this gene/protein

• Cellular processes → Homeostasis → Acquisition of iron → Acquisition of iron / Other
• Metabolism → Additional metabolic pathways → Iron metabolism → Acquisition of iron / Other
• Lifestyles → Exponential and early post-exponential lifestyles → Biofilm formation → Other proteins required for biofilm formation

Categories containing this gene/protein

• acquisition of iron, iron metabolism

This gene is a member of the following regulons

• AbrB regulon, Fur regulon

Gene

Coordinates on the chromosome (coding sequence): 3,287,675 -> 3,288,613

The protein

Catalyzed reaction/ biological activity

• Isochorismate H₂O = 2,3-dihydroxy-2,3-dihydrobenzoate pyruvate (according to Swiss-Prot)

Protein family

• isochorismatase family (according to Swiss-Prot)

Expression and Regulation

Operon

• dhbA-dhbC-dhbE-dhbB-dhbF PubMed

Sigma factor

• SigA PubMed

Regulation

• induced by iron starvation (Fur) PubMed
• strongly repressed in response to glucose starvation in M9 medium PubMed

Regulatory mechanism

• Fur: transcription repression PubMed
• AbrB: transcription repression PubMed

Additional information

• the amount of the mRNA is substantially decreased upon depletion of [Rny|search|RNase Y] PubMed
• the dhbA-dhbC-dhbE-dhbB-dhbF operon is strongly unregulated in a kre mutant PubMed

References

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