glutamyl-tRNA synthetase, universally conserved protein
product
glutamyl-tRNA synthetase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.10|Aminoacyl-tRNA synthetases][category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes][category|SW 6|Groups of genes] → [category|SW 6.5|Universally conserved proteins][SW|Categories] containing this gene/protein
[SW|translation], [SW|essential genes], [SW|universally conserved proteins], [SW|most abundant proteins]Gene
Coordinates on the chromosome (coding sequence)
111,047 -> 112,498
Phenotypes of a mutant
essential [Pubmed|12682299]The protein
Catalyzed reaction/ biological activity
ATP L-glutamate tRNA(Glu) = AMP diphosphate L-glutamyl-tRNA(Glu) (according to Swiss-Prot)Protein family
class-I aminoacyl-tRNA synthetase family (according to Swiss-Prot)Structure
[PDB|3AKZ] (complex with tRNA-Gln from ''Thermotoga maritima'', 38% identity, 62% similarity) [Pubmed|20882017][SW|Localization]
cytoplasm (according to Swiss-Prot)[SW|Interactions]
([protein|search|GatA]-[protein|search|GatB]-[protein|search|GatC])-[protein|search|GltX]-[protein|search|trnS-Gln] (the "[SW|transamidosome]") [Pubmed|20882017], see a [http://www.nature.com/nature/journal/v467/n7315/fig_tab/nature09411_F3.html model of the interaction] [Pubmed|20882017]Additional information
[SW|universally conserved protein]Expression and Regulation
Operon
''[protein|search|gltX]-[protein|search|cysE]-[protein|search|cysS]-[protein|search|mrnC]-[protein|search|yacO]-[protein|search|yacP]'' [Pubmed|7510287][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7510287]Regulation
expression transiently increases in the forespore [Pubmed|22848659]Additional information
the mRNA is very stable (half-life > 15 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]belongs to the 100 [[most abundant proteins]] [PubMed|15378759]References
12884008,20882017,22848659,15378759 
