murR

transcriptional repressor of genes required for the utilization of N-acetylmuramic acid

Locus: BSU_01690

Isoelectric point: 6.87

Molecular weight: 30.56 kDa

Protein length: 283 aa

Gene length: 852 bp

Function: regulation of muramic acid utilization

Product: transcriptional repressor

Essential: no

Synonyms: ybbH

Genomic Context

Loading

Categories containing this gene/protein

• Cellular processes → Cell envelope and cell division → Cell wall degradation/ turnover → Utilization of cell wall components
• Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of amino sugars
• Metabolism → Amino acid/ nitrogen metabolism → Utilization of nitrogen sources other than amino acids → Utilization of amino sugars
• Information processing → Regulation of gene expression → Transcription factors and their control → Transcription factors/ other

Gene

Coordinates: 191,183 192,034

The protein

Domains

• HTH rpiR-type domain (aa 3-79) (according to UniProt)
• SIS domain (aa 123-264) (according to UniProt)

Structure

• 2O3F (N-terminal domain)

Expression and Regulation

Operons

• Genes: murQ-murR-murP-amiE-nagZ-ybbC
  Description: PubMed

  Regulatory mechanism

  • MurR: repression, PubMed, in MurR regulon

  Regulation

  • expressed in late exponential and early stationary phase PubMed

Biological materials

Mutant

• MGNA-B951 (ybbH::erm), available at the NBRP B. subtilis, Japan
• BKE01690 (murR::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TGTGGCCATTCTAGTTCTCT, downstream forward: _UP4_TAAGGCATCTTGAAGGGGAG
• BKK01690 (murR::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TGTGGCCATTCTAGTTCTCT, downstream forward: _UP4_TAAGGCATCTTGAAGGGGAG

References

Loading