protein deacetylase for the control of AcsA activity
function
control of AcsA activity
Genomic Context
categories
[category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids][category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.5|Protein acetylases/ deacetylases][SW|Categories] containing this gene/protein
[SW|utilization of specific carbon sources], [SW|utilization of lipids], [SW|protein modification]This gene is a member of the following [SW|regulons]
[SW|CcpA regulon]Gene
Coordinates on the chromosome (coding sequence)
3,041,392 -> 3,042,555
The protein
Catalyzed reaction/ biological activity
deacetylates (and thereby activates) [protein|search|AcsA] (together with [protein|search|SrtN]) [Pubmed|19136592]Protein family
histone deacetylase family (according to Swiss-Prot) class I histone deacetylaseExpression and Regulation
Operon
''[protein|search|acuA]-[protein|search|acuB]-[protein|search|acuC]'' [Pubmed|7934817][SW|Sigma factor]
[protein|search|SigA] [Pubmed|7913927]Regulation
repressed by glucose ([protein|search|CcpA]) [Pubmed|7913927,12850135]Regulatory mechanism
[protein|search|CcpA]: transcription repression [Pubmed|7913927]Biological materials
Mutant
GP1209 (''[protein|search|acuC]''::''kan''), available in [SW|Stülke] labGP1213 (''[protein|search|srtN]''::''cat'')(''[protein|search|acuC]''::''kan''), available in [SW|Stülke] lab1A887 ( ''acuC''::''spc''), [Pubmed|16855235], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A887&Search=1A887 BGSC]References
7913927,16855235,7934817,19136592,18487328 
