acuC

protein deacetylase for the control of AcsA activity

Locus: BSU_29710

Isoelectric point: 5.06

Molecular weight: 42.83 kDa

Protein length: 387 aa

Gene length: 1164 bp

Function: control of AcsA activity

Product: AcsA deacetylase

Essential: no

Synonyms

Genomic Context

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Categories containing this gene/protein

• Metabolism → Carbon metabolism → Utilization of specific carbon sources → Utilization of organic acids
• Metabolism → Lipid metabolism → Utilization of lipids → Utilization of fatty acids
• Information processing → Protein synthesis, modification and degradation → Protein modification → Protein acetylases/ deacetylases

Gene

Coordinates: 3,041,392 3,042,555

The protein

Catalyzed reaction/ biological activity

• deacetylates (and thereby activates) AcsA (together with SrtN) PubMed

Protein family

• histone deacetylase family (single member, according to UniProt)

Structure

• 1C3R (from Aquifex aeolicus, 35% identity) PubMed

Expression and Regulation

Operons

• Genes: acuA-acuB-acuC
  Description: PubMed

  Sigma factors

  • SigA: sigma factor, PubMed, in SigA regulon

  Regulatory mechanism

  • CcpA: repression, PubMed, in CcpA regulon

  Regulation

  • repressed by glucose (3.4-fold) (CcpA) PubMed

  Additional information

  • the mRNA is quite stable (half-life 5 min) PubMed

Biological materials

Mutant

• GP1209 (acuC::kan), available in Jörg Stülke's lab
• GP1213 (srtN::cat)(acuC::kan), available in Jörg Stülke's lab
• 1A887 ( acuC::spc), PubMed, available at BGSC
• BKE29710 (acuC::erm trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TCTCATAGCAGATCCCTTTG, downstream forward: _UP4_CAAAGAACAAAGTAAAAAAC
• BKK29710 (acuC::kan trpC2) available at BGSC, PubMed, upstream reverse: _UP1_TCTCATAGCAGATCCCTTTG, downstream forward: _UP4_CAAAGAACAAAGTAAAAAAC

References

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