Sec-independent membrane protein translocase, required for development of genetic competence
function
membrane insertion of proteins and protein secretion
product
Sec-independent membrane protein translocase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence][category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.5|Protein secretion][category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins][SW|Categories] containing this gene/protein
[SW|protein secretion], [SW|genetic competence], [SW|membrane proteins]This gene is a member of the following [SW|regulons]
[SW|MifM regulon]Gene
Coordinates on the chromosome (coding sequence)
2,483,904 -> 2,484,731
The protein
Protein family
YidC/Oxa1/Alb3 family [Pubmed|20800571,21194367,15802250]Paralogous protein(s)
[SW|SpoIIIJ], one of the two proteins has to be present for viability [Pubmed|17114254]Structure
[PDB|3WO6] (from ''Bacillus halodurans'', 41% identity) [Pubmed|24739968][SW|Localization]
membrane [Pubmed|22864117]Expression and Regulation
Operon
''[protein|search|mifM]-[SW|yidC2]'' [Pubmed|22383849]Regulation
repressed by large amounts of [SW|SpoIIIJ], induced by small amounts of [SW|SpoIIIJ] ([protein|search|MifM]) [Pubmed|19779460]Regulatory mechanism
[protein|search|MifM]: attenuation mechanism, an mRNA hairpin of the ''yqjG'' transcript unfold upon translation arrest of [protein|search|MifM] at decreased [SW|SpoIIIJ] levels [Pubmed|19779460]References
Reviews
22688815,20800571,21194367,15802250,25947384,27879020 Original publications
17114254,15995216,11889108,12586834,19717609,19779460,21204254,22383849,22864117,24443530,25313395,25359772,25855636,25903689,26023232,24739968,26331454 
