metA [Mon Aug 31 2015 13:55:10 GMT+0200 (CEST)]

homoserine O-succinyltransferase

locus: BSU21910

pI: 6.41

mw: 25.00 kDa

function: biosynthesis of methionine

product: homoserine O-succinyltransferase

essential: no

ec: 2.3.1.46

synonyms: metB

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.3|Amino acid/ nitrogen metabolism] → [category|SW 2.3.1|Biosynthesis/ acquisition of amino acids] → [category|SW 2.3.1.10|Biosynthesis/ acquisition of methionine/ S-adenosylmethionine]
• [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.2|Cell envelope stress proteins (controlled by SigM, V, W, X, Y)]

syns: metB

[SW|Categories] containing this gene/protein

• [SW|biosynthesis/ acquisition of amino acids], [SW|cell envelope stress proteins (controlled by SigM, V, W, X, Y)]

This gene is a member of the following [SW|regulons]

• [SW|SigM regulon]

The protein

Catalyzed reaction/ biological activity

• Succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine (according to Swiss-Prot) O(4)-succinyl-L-homoserine + L-cysteine = L-cystathionine + succinate (according to Swiss-Prot)

Structure

• [PDB|2GHR] (from ''Bacillus cereus'', 60% identity, 77% similarity) [Pubmed|17546672]

Expression and Regulation

Operon

• ''[protein|search|metA]-[protein|search|ugtP]'' [Pubmed|22383849]

[SW|Sigma factor]

• [protein|search|SigM] [Pubmed|18179421]

References

• 17546672,18179421